Basic Information
VIS ID
TVIS20002086
Fusion event
HPV-LRRC7 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
70148169/69682486 (Hg38)
End
70148169/69682486 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1C ; FRA1L
Target gene
LRRC7
Nearest miRNA
hsa-mir-101-1/Upstream/1498876; hsa-mir-11399/Downstream/1385145;
Nearest TSS
ENST00000473358/Upstream/114036; ENST00000415775/Downstream/77689;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/113674, chr1-CpG: 17/Downstream/236874
Upstream sequence
GTATACTCACAAATAGAGGGAAAATATCTTAAGTGACAAAGAAGAATGTTACTACATCAATAATCCAGTGATCTCCATCATCATAGTGCCTCATCCCAGG
Downstream sequence
TGTAATTGATGTCACCCCAATATCTCCATTATCATAGTGCCTCATCCTGGATGTAATTGATGTCACCCTTCTGTTCCATGACTCGGACCCAAAAGGAGGG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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