Basic Information
VIS ID
TVIS20002087
Fusion event
HPV-chr1:q24.3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr1
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
171218916/171249777 (Hg38)
End
171218916/171249777 (Hg38)
Location type
Intronic
Target gene
FMO1 ; LOC105371611
miRNAs that regulate target gene
hsa-mir-320a
Nearest miRNA
hsa-mir-101-1/Upstream/147971; hsa-mir-1182/Downstream/889021;
Nearest TSS
ENST00000473358/Upstream/1278; ENST00000459868/Downstream/2017;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/584740, chr1-CpG: 56/Downstream/235601
Upstream sequence
GGGCCCAAGAGATTCACTCTTTGAAGAAACATGGTACTTAGCTATGGTGGGTGAAAAGCACAGAAGAAGTTACACTCCGTGTCCTTCTCCAAATAATGAC
Downstream sequence
ACTTGGGATGAAGGAGTCAGACTTGTGCATTCAAACACAGTAACTGATCATATTCCAAGCCCTGCTAAGACAGTGCCAAGACTCCCTGCCACAGCAGCAG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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