Basic Information
VIS ID
TVIS20002104
Fusion event
HPV-TNS4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
38635893/40479641 (Hg38)
End
38635893/40479641 (Hg38)
Location type
Intronic
Target gene
TNS4
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-6874-5p ; hsa-mir-6867-5p ; hsa-mir-887-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-6788-5p ; hsa-mir-1273h-5p ; hsa-mir-30c-2-3p ; hsa-mir-7977 ; hsa-mir-30c-1-3p ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-6090 ; hsa-mir-6827-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-544b ; hsa-mir-5690 ; hsa-mir-4293 ; hsa-mir-890 ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-150-5p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-6814-5p ; hsa-mir-3691-3p ; hsa-mir-1910-5p ; hsa-mir-455-3p
Nearest miRNA
hsa-mir-1180/Upstream/285978; hsa-mir-10226/Downstream/1037523;
Nearest TSS
ENST00000595228/Upstream/993; ENST00000578280/Downstream/371;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/35587, chr17-CpG: 69/Downstream/168051
Nearest cancer related gene
TNS4(OG, No orient, 0)
Upstream sequence
AGGTAGTGCTCCTGTTCATAGAACAAAGTGCTGCTCACCGAATAGTACAAAGTCATGCAACAACTGCATCCAGTACATAAATGCAGAAGCTTTTTAAATT
Downstream sequence
CCCGGAGCCCCAGGGCAAGGGAAGGCCCTTACTTCCTCTGGACATCAGTCAGAGTGATGCCCTGCTCTGTGACTTTGAAGTGGACCACGGTGGGCGTGGG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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