Basic Information
VIS ID
TVIS20002116
Fusion event
HPV-PTPRG integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
61574405/61588731 (Hg38)
End
61574405/61588731 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA3B
Target gene
PTPRG
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-19b-3p ; hsa-mir-342-5p ; hsa-mir-624-5p ; hsa-mir-193b-3p ; hsa-mir-10a-5p ; hsa-mir-19a-3p ; hsa-mir-130a-3p ; hsa-mir-301a-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-4671-3p ; hsa-mir-7844-5p ; hsa-mir-218-5p ; hsa-mir-6867-3p ; hsa-mir-4685-3p ; hsa-mir-642a-5p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-5582-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-6854-3p ; hsa-mir-4282
Nearest miRNA
hsa-let-7g/Upstream/970861; hsa-mir-12124/Downstream/5636733;
Nearest TSS
ENST00000440867/Upstream/26820; ENST00000468576/Downstream/628852;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/23828, chr3-CpG: 35/Downstream/730108
Upstream sequence
tttataattactttctactgtcaatttcatttcccctttgtcctcagccagcacctctactagtcatggttctttgcctggtggggtaaactggtaaact
Downstream sequence
cgccgcgcccggccCTAGGAGGGATAAATATTCATTAACATTCATATATATGAAAAAAATATATACACACACATACTCATATATGCATCCGTGTATATGT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate