Basic Information
VIS ID
TVIS20002135
Fusion event
HPV-CNTNAP2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr7
Cytoband
q35
Reference genome
GRCh37/hg19
Start
146041323/146344231 (Hg38)
End
146041323/146344231 (Hg38)
Location type
Intronic
Target gene
CNTNAP2
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-99b-5p ; hsa-mir-4444 ; hsa-mir-6079 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-4428 ; hsa-mir-571 ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u
Nearest miRNA
hsa-mir-10399/Upstream/2961431; hsa-mir-153-2/Downstream/1033786;
Nearest TSS
ENST00000635602/Upstream/226971; ENST00000636600/Downstream/430040;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/227239, chr7-CpG: 33/Downstream/1995171
Nearest cancer related gene
CNTNAP2(TSG, No orient, 0)
Upstream sequence
aagatgggaaaagagctaccactactaaacgttggaagctggaaagtagatagatgacttataactaaatgaacagacccaagaaagctaaatccaaatc
Downstream sequence
TCTAAACTATCTTTACTAGATTTGAAACTCCAGCATATTATATTTACCAAGGTAAATTATCCCTCTTATGACAAGTTTTTGTTATCCTAACTGATAATTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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