Basic Information
VIS ID
TVIS20002166
Fusion event
HPV-MORC2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
31332301/30936314 (Hg38)
End
31332301/30936314 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA22B
Target gene
MORC2
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-125a-5p ; hsa-mir-218-5p ; hsa-mir-6515-3p ; hsa-mir-877-3p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4742-5p ; hsa-mir-3675-5p
Nearest miRNA
hsa-mir-1286/Upstream/204673; hsa-let-7a-3/Downstream/223748;
Nearest TSS
ENST00000624155/Upstream/3420; ENST00000422839/Downstream/5937;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/13812, chr22-CpG: 100/Downstream/32264
Upstream sequence
TACCTCTAAGGCAGAATTTTTATTTTCTAGAGTTTTATACATTCTAAATGAATTGGACCACTTTGAAGTATATAAGCATTTTTTCTTAAGAATAAGCAAG
Downstream sequence
GTGTTATTCTTAAAATAACACTGTTGGCAAATAGTACACGTGGACCTGGAGGTTGGGGTTGGAAAGCTTTGGCAAACAACGCGGGTGAGTGGAGGGTAAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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