Basic Information
VIS ID
TVIS20002174
Fusion event
HPV-GRIA4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
105571750/105701024 (Hg38)
End
105571750/105701024 (Hg38)
Location type
Intronic
Target gene
GRIA4
miRNAs that regulate target gene
hsa-mir-484
Nearest miRNA
hsa-mir-10392/Upstream/1851044; hsa-let-7a-2/Downstream/5646733;
Nearest TSS
ENST00000527297/Upstream/90026; ENST00000527687/Downstream/141759;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/90329, chr11-CpG: 26/Downstream/320974
Upstream sequence
TTTGGTTAAATTGATTTCATTCATAGTTGGTTTGGATGGTGTATTCAAAAGATAGATCGTATCAGACTGCCAGTGTACAGGAGTCTGGGGGGACAGACCT
Downstream sequence
CCTCTTGTGTGTGCACATGTGGGCCTAAATATTTCCTCTTCTCACAGGTGGGTGGGATTTCGCCTTTGAGGGGCCTGAAAAGACATTTTCACAGGATGGG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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