Basic Information
VIS ID
TVIS20002175
Fusion event
HPV-ZNF664-RFLNA integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
124689942/124205396 (Hg38)
End
124689942/124205396 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
ZNF664-RFLNA
Nearest miRNA
hsa-let-7i/Upstream/668862; hsa-mir-3612/Downstream/131785;
Nearest TSS
ENST00000382841/Upstream/119635; ENST00000539391/Downstream/832;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/231215, chr12-CpG: 103/Downstream/89487
Upstream sequence
CCACTGTGAGTGCTTTAGCACAGAATACAATCTTGATGAAAATCTGTGCCAGGACCAGAAATCCAACCACCGAATGATCACACAGATCTGCATGGCATGT
Downstream sequence
TTCCTATGTCTTCCAATACCAGGACCACCGCATTAACACTGATTAAACATCCTACACTTGTAAGTTGATTGTAACTCTATAAGGACTTTCTTGCCTTCTC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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