Basic Information
VIS ID
TVIS20002178
Fusion event
HPV-GLI2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr2
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
121688357/120930781 (Hg38)
End
121688357/120930781 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
GLI2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-31-5p ; hsa-mir-218-5p ; hsa-mir-574-5p ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-6819-5p ; hsa-mir-6812-5p ; hsa-mir-6737-5p ; hsa-mir-6740-5p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-342-5p ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-466 ; hsa-mir-6793-3p ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-95-5p ; hsa-mir-223-5p ; hsa-mir-541-3p ; hsa-mir-654-5p ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-92a-2-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/7209413; hsa-mir-10b/Downstream/6492756;
Nearest TSS
ENST00000437798/Upstream/63378; ENST00000432984/Downstream/157945;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/63147, chr2-CpG: 22/Downstream/53749
Nearest cancer related gene
GLI2(OG, No orient, 0)
Upstream sequence
gcactccagcttgggtgacacatcaaggctgtctctaaataaataaatacaaaTAATTACATTCAAATAAAGTAAAAAGTCCAAGCACTACAAAAAGGTT
Downstream sequence
CTGAGAAGGGAGGCCCTCAGTGCCGTCCTTCCCTGTGTAGGTGGGAGCCCTGGGCTGGGAAGGGGCCTGGGTCTTCACCAGGCTTTGCCATGCTCCAGCT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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