Basic Information
VIS ID
TVIS20002181
Fusion event
HPV-SIL1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr5
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
138323277/138987588 (Hg38)
End
138323277/138987588 (Hg38)
Location type
Intronic
Target gene
SIL1
miRNAs that regulate target gene
hsa-mir-615-3p
Nearest miRNA
hsa-mir-10397/Upstream/1339939; hsa-mir-103a-1/Downstream/1576083;
Nearest TSS
ENST00000502646/Upstream/34155; ENST00000514207/Downstream/25059;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/233441, chr5-CpG: 43/Downstream/210593
Upstream sequence
TCACTGCTGGACAACTGACAAGTAAAGTTCCTTCCCTCTACGGCCTTCTGACGCCCAGTGCCAGCTCTGCTAGAGAAGTTACCTCAGCAAAGCCCTGAGA
Downstream sequence
AAAGGGCATGATATATGGCTTTTGTAttcctgcatagcctggctctcatagaagcattaaagtgACTGCCCTGGCAAACACTCTAAATGGAGCCCTCTTA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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