Basic Information
VIS ID
TVIS20002251
Fusion event
HPV-KIAA1217 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr10
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
24369810/24080881 (Hg38)
End
24369810/24080881 (Hg38)
Location type
Intronic
Target gene
KIAA1217
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-4286 ; hsa-mir-6507-3p
Nearest miRNA
hsa-mir-1265/Upstream/2584240; hsa-mir-107/Downstream/194804;
Nearest TSS
ENST00000439456/Upstream/38750; ENST00000635504/Downstream/127910;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/384832, chr10-CpG: 209/Downstream/641787
Upstream sequence
aaagactctttggataggcaccatcaacccattttacagatgaattaaatggggcacacaaaagttaattaagttgcccaaagggtgacacagcaaggaa
Downstream sequence
gtggcacaggtgggattcaaattcaagcctacctgactccaggccccacaatgttgcctctAGTTGTTAcctgcattttataataaggaaggcagccaag
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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