Basic Information
VIS ID
TVIS20002345
Fusion event
HPV-KISS1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
204164831/204195703 (Hg38)
End
204164831/204195703 (Hg38)
Location type
Intronic
Target gene
KISS1
Nearest miRNA
hsa-mir-101-1/Upstream/2192467; hsa-mir-1182/Downstream/1252599;
Nearest TSS
ENST00000473358/Upstream/2827; ENST00000437919/Downstream/783;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/4998, chr1-CpG: 25/Downstream/61713
Nearest cancer related gene
KISS1(TSG, No orient, 0)
Upstream sequence
TTGCTGTTCTAGAAAGTACAGAGACACGTAGTGAAAATGGGAGGATCTAGAAGGAGGCTGTCTCCTGTGTAGTGTATATTTATCTGTAAGTGAGCCGTTG
Downstream sequence
GGGAAGGATTGAATACAGAGACGCTGTCTGCTTGCTGCCTTAAGACAGCTAGCTGAATTGCTGATTAACTTTTAAAATACCCAGCTTGGTTTATTTTTCT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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