Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene892170118926761989490561893133228932788589328943893369658929741789304190893431548934667489309350893122738933782589340110893495768935145089353353893551388930673589308231893476058934898889304197893055618932810889328696893416658934223989352801893531628934700189347200893522018935240089308473893086628930901389309202893517538935190289353786
Basic Information
VIS ID
TVIS20002361
Fusion event
HPV-ANKRD11 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr16
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
89420194/89353786 (Hg38)
End
89420194/89353786 (Hg38)
Location type
Intronic
Target gene
ANKRD11
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-1914-3p ; hsa-mir-615-3p ; hsa-mir-193b-3p ; hsa-mir-186-5p ; hsa-mir-149-5p ; hsa-mir-4699-3p ; hsa-mir-4766-5p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-582-5p ; hsa-mir-101-3p ; hsa-mir-144-3p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-4684-3p ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-605-3p ; hsa-mir-8067 ; hsa-mir-6508-5p ; hsa-mir-3154 ; hsa-mir-8066 ; hsa-mir-3714 ; hsa-mir-6809-5p ; hsa-mir-4330 ; hsa-mir-4698 ; hsa-mir-651-3p ; hsa-mir-4311 ; hsa-mir-365b-3p ; hsa-mir-365a-3p
Nearest miRNA
hsa-mir-11401/Upstream/637449;
Nearest TSS
ENST00000527434/Upstream/9963; ENST00000646707/Downstream/19699;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/11729, chr16-CpG: 49/Downstream/35953
Upstream sequence
ttgaggctatagtgagctgagattgcaccattgcactccagcttgggtgacagagtgagatcctgttaaaaaaaaaaaagagaaagaaggaaagacaaaa
Downstream sequence
ATATCTTATGGAACATAATGTTTTTCATGATCAACAGCCACTATGGGAACACAACACACATCAGCCCTGAGACACCCGAAACAAGACAGAGCAGCCTCTG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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