Basic Information
VIS ID
TVIS20002390
Fusion event
HPV-KCNQ5 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
73710597/73000874 (Hg38)
End
73710597/73000874 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA6D
Target gene
KCNQ5
miRNAs that regulate target gene
hsa-mir-190a-5p ; hsa-mir-194-3p ; hsa-mir-574-5p ; hsa-mir-6515-5p ; hsa-mir-6867-5p ; hsa-mir-7847-3p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-6782-5p ; hsa-mir-5693 ; hsa-mir-675-3p ; hsa-mir-223-5p ; hsa-mir-543 ; hsa-mir-5096 ; hsa-mir-101-3p ; hsa-mir-139-5p ; hsa-mir-4999-3p ; hsa-mir-144-3p ; hsa-mir-6507-5p ; hsa-mir-4282
Nearest miRNA
hsa-mir-10398/Upstream/33121; hsa-mir-10524/Downstream/2427533;
Nearest TSS
ENST00000381078/Upstream/378702; ENST00000443915/Downstream/3122;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/377493, chr6-CpG: 22/Downstream/156987
Upstream sequence
agctaaaaactacattttcagatttccgagcatctTATCATGTACTATTACTAAGGTGAGACTGAATTCAGAACTGAGTTAAGTGAGAAGAAAGGCAGGG
Downstream sequence
ATTTTCTACTGAACTAAATGCAGACTCTGCCCTACAAGCCTCTCCTCCACTTAGCTCCAGACTCCCAATTCAGCCACCTGTTTCATCCTGTTCTGCAAAC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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