Basic Information
VIS ID
TVIS20002399
Fusion event
HPV-PLA2G5 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37/hg19
Start
20415060/20088567 (Hg38)
End
20415060/20088567 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
PLA2G5
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-192-3p ; hsa-mir-2467-3p ; hsa-mir-922 ; hsa-mir-6847-5p ; hsa-mir-6859-5p ; hsa-mir-3125 ; hsa-mir-3916
Nearest miRNA
hsa-mir-12136/Upstream/1191419; hsa-mir-101-1/Downstream/545112;
Nearest TSS
ENST00000473358/Upstream/18272; ENST00000465062/Downstream/30990;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/205598, chr1-CpG: 36/Downstream/97300
Upstream sequence
tttgatatgtaaactggtttctctctcttcatgtttgctctcagagtctctctcgacttttagaatctttccttctgttttgaaattttgtgctgagatt
Downstream sequence
tcctgttgtgaaattttatgtttctgggtgtattttcacattgtactaaacattttgtaagcctgttcaatttagaagtacatatcctgcttttagacat
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate