Basic Information
VIS ID
TVIS20002409
Fusion event
HPV-NOS1AP integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
162232621/162262831 (Hg38)
End
162232621/162262831 (Hg38)
Location type
Intronic
Target gene
NOS1AP
miRNAs that regulate target gene
hsa-mir-423-5p ; hsa-mir-320a ; hsa-mir-6734-5p ; hsa-mir-4710 ; hsa-mir-7977 ; hsa-mir-6825-5p ; hsa-mir-6799-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-7854-3p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-3184-5p ; hsa-mir-6743-5p ; hsa-mir-4688 ; hsa-mir-1197 ; hsa-mir-6768-5p ; hsa-mir-3692-3p ; hsa-mir-4436b-5p ; hsa-mir-6509-3p ; hsa-mir-3151-3p ; hsa-mir-138-2-3p ; hsa-mir-1273g-3p ; hsa-mir-181a-2-3p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p ; hsa-mir-888-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-6730-3p ; hsa-mir-125b-2-3p ; hsa-mir-28-5p ; hsa-mir-3139 ; hsa-mir-3160-3p ; hsa-mir-4457 ; hsa-mir-513b-5p ; hsa-mir-5697 ; hsa-mir-6888-5p ; hsa-mir-708-5p
Nearest miRNA
hsa-mir-101-1/Upstream/105649; hsa-mir-1182/Downstream/79715;
Nearest TSS
ENST00000473358/Upstream/192741; ENST00000464284/Downstream/54963;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/192569, chr1-CpG: 43/Downstream/104255
Upstream sequence
atatacacacatacacccatacacgtacatcatacacacacatacaccacatacaccacacatgcgcacacacatcacacacatatacacacatacaccc
Downstream sequence
atacacacatatcacacacacacacacacacacacacacacacacacacaGATTCCACTGCCCAGCCCATCGGGGCACTTAACATATATGGTAGAAATGA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate