Basic Information
VIS ID
TVIS20002432
Fusion event
HPV-CCDC6 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Host Sequence
Chromosome
chr10
Cytoband
q21.2
Reference genome
End
61613348/59853590 (Hg38)
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-181a-5p ; hsa-mir-331-5p ; hsa-mir-342-3p ; hsa-mir-99a-5p ; hsa-mir-92a-3p ; hsa-mir-548c-3p ; hsa-mir-671-5p ; hsa-mir-3190-3p ; hsa-mir-6079 ; hsa-mir-142-3p ; hsa-mir-146a-5p ; hsa-mir-146b-5p ; hsa-mir-580-5p ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-7156-5p ; hsa-mir-4273 ; hsa-mir-6803-5p ; hsa-mir-6751-5p ; hsa-mir-7109-5p ; hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-2117 ; hsa-mir-6740-5p ; hsa-mir-6745 ; hsa-mir-363-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6835-5p ; hsa-mir-6828-5p ; hsa-mir-6077 ; hsa-mir-873-5p ; hsa-mir-7854-3p ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-4328 ; hsa-mir-6165 ; hsa-mir-2113 ; hsa-mir-630 ; hsa-mir-5093 ; hsa-mir-4790-3p ; hsa-mir-506-5p ; hsa-mir-892c-5p ; hsa-mir-3688-3p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-5692a ; hsa-mir-218-5p ; hsa-mir-576-3p ; hsa-mir-6833-5p ; hsa-mir-6864-5p ; hsa-mir-6126 ; hsa-mir-3148 ; hsa-mir-6124 ; hsa-mir-1252-5p ; hsa-mir-299-3p ; hsa-mir-4657 ; hsa-mir-4491 ; hsa-mir-512-3p ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-28-5p ; hsa-mir-28-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-708-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-335-3p ; hsa-mir-4652-3p ; hsa-mir-1298-5p ; hsa-mir-4778-5p ; hsa-mir-8087 ; hsa-mir-130b-3p
Nearest miRNA
hsa-mir-1265/Upstream/2549031; hsa-mir-107/Downstream/3519367;
Nearest cancer related gene
CCDC6(OG, No orient, 0)
Upstream sequence
cttttgctgatctaagcattaaagagtgggctcgcttactgttgagttttactgacataataaataagcttcaagttagtccaatgttatcacttatcct
Downstream sequence
ttagtaaacattgccttccacatggaagttaattcagagaactcccagtaacacacttggctcccaacagtgaactcagctacatgcattcatttagaga
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate