Basic Information
VIS ID
TVIS20002444
Fusion event
HPV-PRPF19 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr11
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
60669328/60901856 (Hg38)
End
60669328/60901856 (Hg38)
Location type
Intronic
Target gene
PRPF19
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-30a-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-129-2/Upstream/692700; hsa-let-7a-2/Downstream/606740;
Nearest TSS
ENST00000527297/Upstream/2641; ENST00000544421/Downstream/558;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/48218, chr11-CpG: 59/Downstream/4269
Upstream sequence
tctatcataaatacacatacacaggtgtgtttattgcagcattattcgcaatagcaaagacatggaattaaccaaatgcctaccaatcacagatgggata
Downstream sequence
aagaaaatgtggtacatatataccatagaacactatgcggccataaaaaataatgagatcatgtcctttataggaacaccaatggagattgaggccatta
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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