Basic Information
VIS ID
TVIS20002453
Fusion event
HPV-ERC1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr12
Cytoband
p13.33
Reference genome
GRCh37/hg19
Start
1393945/1284779 (Hg38)
End
1393945/1284779 (Hg38)
Location type
Intronic
Target gene
ERC1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-335-5p ; hsa-mir-183-5p ; hsa-mir-26b-5p ; hsa-let-7d-5p ; hsa-mir-320b ; hsa-mir-1229-3p ; hsa-mir-320a ; hsa-mir-221-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-513a-5p ; hsa-mir-4278 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4487 ; hsa-mir-4445-5p ; hsa-mir-6754-5p ; hsa-mir-342-3p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6732-5p ; hsa-mir-6805-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-6760-5p ; hsa-mir-6510-5p ; hsa-mir-6873-5p ; hsa-mir-143-5p ; hsa-mir-6879-3p ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-4462 ; hsa-mir-6773-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-5190 ; hsa-mir-500b-3p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-1267 ; hsa-mir-203b-3p ; hsa-mir-3183 ; hsa-mir-3612 ; hsa-mir-4723-3p ; hsa-mir-5196-3p ; hsa-mir-650 ; hsa-mir-6769b-3p ; hsa-mir-6787-3p ; hsa-mir-7111-3p ; hsa-mir-7158-3p
Nearest miRNA
hsa-let-7i/Downstream/375536;
Nearest TSS
ENST00000382841/Upstream/27641; ENST00000515210/Downstream/106723;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/293160, chr12-CpG: 238/Downstream/245088
Upstream sequence
AGCAGTGGGAATGCAAAGGCTTGTGCCGGGTAAACACTTCTCATGAGTGTTTCAGCTTTGGCATTGCCTTTATGCCAGTTATTCTGGCAGATCACCACTG
Downstream sequence
CCAAAGAAATACCTTTATAATTTTCTAACATTGATTGTCAGCAGCACTATAGAGACCGTAATATTACACGAAGTACCTTAATGATCTAATGAATAAAAAC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate