Basic Information
VIS ID
TVIS20002458
Fusion event
HPV-CPNE8 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr12
Cytoband
q12
Reference genome
GRCh37/hg19
Start
39130515/38736713 (Hg38)
End
39130515/38736713 (Hg38)
Location type
Intronic
Target gene
CPNE8
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-124-3p ; hsa-mir-16-5p ; hsa-mir-8485 ; hsa-mir-4719
Nearest miRNA
hsa-mir-1244-3/Upstream/12862634; hsa-let-7i/Downstream/3586987;
Nearest TSS
ENST00000382841/Upstream/15491; ENST00000551152/Downstream/31004;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/419872, chr12-CpG: 29/Downstream/168733
Upstream sequence
aagttcttttagaaaatcattttgtttttgccaagcccgtaatatttaaaaaataatttgaaatattttgtgaagccCCATATCCCAAGAGATTCATCCA
Downstream sequence
TCTCTCCCAAATTATGAGAACATGTGTTTTATTTCCACACCTAAATTTATCCAATTTGGGCTTTCTCTTAGAATTAAAAAACCTTTAAAGCAAGAGGGGA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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