Basic Information
VIS ID
TVIS20002482
Fusion event
HPV-PCCA integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr13
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
101151170/100498916 (Hg38)
End
101151170/100498916 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
PCCA
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-455-5p ; hsa-mir-7152-5p ; hsa-mir-568 ; hsa-mir-1273e ; hsa-mir-155-5p ; hsa-mir-4326 ; hsa-mir-15b-3p ; hsa-mir-486-5p
Nearest miRNA
hsa-mir-1297/Upstream/855767; hsa-mir-1267/Downstream/1468726;
Nearest TSS
ENST00000623511/Upstream/8948; ENST00000428969/Downstream/16511;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/409365, chr13-CpG: 51/Downstream/33226
Upstream sequence
TGTTTCTTCTCATATAACCAATGCAAAATGCGAATATAGCTTTCTAATTCTTAGTGTAAAACTTTGAATTTATAATCTTTATCCATGTCTTAGGTTAGAC
Downstream sequence
TCCAAATTTTCTTATTTTCCCCCCAAAAATATTCAACTTATGAAACAAGATCATGAGGTGTCCTAATTTAGACTTTGAACTAAAGTCAACTAGGTAATGA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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