Basic Information
VIS ID
TVIS20002510
Fusion event
HPV-MYH10 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
8433056/8529738 (Hg38)
End
8433056/8529738 (Hg38)
Location type
Intronic
Target gene
MYH10
miRNAs that regulate target gene
hsa-mir-1274a ; hsa-mir-106b-3p ; hsa-mir-92b-3p ; hsa-mir-505-3p ; hsa-mir-197-3p ; hsa-mir-26a-5p ; hsa-mir-23a-3p ; hsa-mir-200a-3p
Nearest miRNA
hsa-mir-1253/Upstream/342734; hsa-mir-10226/Downstream/3552161;
Nearest TSS
ENST00000595228/Upstream/8219; ENST00000585297/Downstream/15795;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/52517, chr17-CpG: 188/Downstream/99948
Upstream sequence
ccTGCCTCTTTTTTTCTACTAGGGCTATCACAATTCTGGCCTTCATTTCATTTGACAGGAAGGCATGGGTTTATACCCTAACCAGAACAACAATGAACAG
Downstream sequence
GATGGATTTGGATCTCAGCATTATCATGTTCCAAAAATCATAAAGGAAATTTCATAAGATAAATTTATCTTTGAGTTTCGCTACTTGCCAGTTTCACTAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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