Basic Information
VIS ID
TVIS20002527
Fusion event
HPV-ZNF708 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Host Sequence
Chromosome
chr19
Cytoband
p12
Reference genome
End
21498142/21315340 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-18a-5p ; hsa-mir-222-3p ; hsa-mir-4504 ; hsa-mir-549a ; hsa-mir-3927-5p ; hsa-mir-5089-5p ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-15b-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-4698 ; hsa-mir-150-5p ; hsa-mir-186-3p ; hsa-mir-6869-5p ; hsa-mir-4502 ; hsa-mir-3921 ; hsa-mir-4653-5p ; hsa-mir-301b-5p ; hsa-mir-301a-5p ; hsa-mir-146a-3p ; hsa-mir-6817-3p ; hsa-mir-576-3p ; hsa-mir-4662b ; hsa-mir-4647 ; hsa-mir-4426 ; hsa-mir-1303 ; hsa-mir-5096 ; hsa-mir-197-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-5580-5p ; hsa-mir-3190-5p ; hsa-mir-483-5p ; hsa-mir-640 ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-4680-5p ; hsa-mir-1224-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6079 ; hsa-mir-7977 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-3202 ; hsa-mir-4533 ; hsa-mir-4493 ; hsa-mir-5693 ; hsa-mir-383-3p ; hsa-mir-1273f ; hsa-mir-6818-3p ; hsa-mir-2110 ; hsa-mir-4684-5p ; hsa-mir-491-5p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-339-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-6732-3p ; hsa-mir-548c-3p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6769b-5p ; hsa-mir-6769a-5p ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-3656 ; hsa-mir-6087 ; hsa-mir-6765-3p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p ; hsa-mir-1289 ; hsa-mir-129-5p ; hsa-mir-1304-3p ; hsa-mir-143-3p ; hsa-mir-1910-3p ; hsa-mir-2682-5p ; hsa-mir-3198 ; hsa-mir-34b-5p ; hsa-mir-4294 ; hsa-mir-4309 ; hsa-mir-4423-5p ; hsa-mir-449c-5p ; hsa-mir-4534 ; hsa-mir-4639-3p ; hsa-mir-4708-5p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-6501-5p ; hsa-mir-6511a-5p ; hsa-mir-6514-5p ; hsa-mir-6794-3p ; hsa-mir-6808-5p ; hsa-mir-6893-5p ; hsa-mir-744-3p ; hsa-mir-802 ; hsa-mir-8055 ; hsa-mir-8082 ; hsa-mir-940
Nearest miRNA
hsa-mir-10395/Upstream/915986; hsa-let-7e/Downstream/13807360;
Upstream sequence
TTTCCtccctgctttttattatggaaattctcaaaaatgcacaaaagtagacagaataatgtatacccaCTGTGAAAGCAttcagctatcttctcctttt
Downstream sequence
CAAAGTCTGGCCCTGTCTTGTAATCCCAGGCAGAAGCCAGATCTTATGTGCAGATTCTAAGTGGGATCAACCTGACTCTGCATCCTTAGGTGTTACAGAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate