Basic Information
VIS ID
TVIS20002569
Fusion event
HPV-ROBO1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr3
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
79371926/79322776 (Hg38)
End
79371926/79322776 (Hg38)
Location type
Intronic
Target gene
ROBO1
miRNAs that regulate target gene
hsa-mir-217 ; hsa-mir-218-5p ; hsa-mir-423-3p ; hsa-mir-25-3p ; hsa-mir-6835-3p ; hsa-mir-146a-5p ; hsa-mir-377-3p ; hsa-mir-1185-2-3p ; hsa-mir-876-3p ; hsa-mir-3591-5p ; hsa-mir-921 ; hsa-mir-3606-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-636 ; hsa-mir-3140-3p ; hsa-mir-4445-5p ; hsa-mir-508-3p ; hsa-mir-8062 ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-561-3p ; hsa-mir-548at-5p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-299-5p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-4782-3p ; hsa-mir-6766-3p ; hsa-mir-219a-5p ; hsa-mir-6885-3p ; hsa-mir-1273e ; hsa-mir-4327 ; hsa-mir-1287-5p ; hsa-mir-3135b ; hsa-mir-330-3p ; hsa-mir-29a-3p ; hsa-mir-218-2-3p
Nearest miRNA
hsa-let-7g/Upstream/3584413; hsa-mir-12124/Downstream/185111;
Nearest TSS
ENST00000440867/Upstream/303317; ENST00000473938/Downstream/267166;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/303360, chr3-CpG: 29/Downstream/443712
Nearest cancer related gene
ROBO1(TSG, No orient, 0)
Upstream sequence
CCTGGTGCCTGCACAGTCCAAGATTTCAAGTAAACTCCAGACACTGAGAACACCTAATTTTTAACTAGTTTCCAACATTTCTCATTTGTAATCACCAAAT
Downstream sequence
TTTCAGGAATGAAGAAATGGAAGAAGGGATATAAAAAACTATACTTTTAAGATAATTCTTGTTTTATAGCACTTCCTAAAGCAAAAACAAAATAAAATGG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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