Basic Information
VIS ID
TVIS20002614
Fusion event
HPV-FSTL5 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr4
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
162695494/161774342 (Hg38)
End
162695494/161774342 (Hg38)
Location type
Intronic
Target gene
FSTL5
Nearest miRNA
hsa-mir-12113/Upstream/2645448; hsa-mir-1305/Downstream/1319232;
Nearest TSS
ENST00000502981/Upstream/109438; ENST00000513093/Downstream/248391;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2670359, chr4-CpG: 71/Downstream/1391967
Upstream sequence
GAGTTTTGAGTATCAGAATCTTTTCTTAGCTGCCTAAGTAATTGCAAATATATAATTGTATTTCCAGATTGTTACGATTCAAAATGACCTATTTTTTAAA
Downstream sequence
aacaccacaattctgaacttccaacttccaggattgagaggataaatttctgctgttttagccacacagtttgtggtattttcttatgcgagccctagga
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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