Basic Information
VIS ID
TVIS20002621
Fusion event
HPV-GHR integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr5
Cytoband
p12
Reference genome
GRCh37/hg19
Start
42561488/42561386 (Hg38)
End
42561488/42561386 (Hg38)
Location type
Intronic
Target gene
GHR
Nearest miRNA
hsa-mir-10397/Upstream/4003825; hsa-mir-103a-1/Downstream/11390118;
Nearest TSS
ENST00000502646/Upstream/11306; ENST00000513625/Downstream/4470;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/136441, chr5-CpG: 47/Downstream/362726
Upstream sequence
GGGTCTCCTCTAGCCCTGTGAGTCTACAGGGTGTAAGTTTATCTAAAAGACAAAATGGAAGATTGAAAGTCTAAACAAAATTGCTAGTAAATGTCTATTA
Downstream sequence
GTTTAACAAATACTTGCTAATTCTAAATTAAAGAGCATGAAACATATTGTTTTCTTTGCCTGGAGTTGGTTATAGCATGCTGGAAAAAGTATTATATCTA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate