Basic Information
VIS ID
TVIS20002687
Fusion event
HPV-RRM2B integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr8
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
103240941/102228713 (Hg38)
End
103240941/102228713 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA8A
Target gene
RRM2B
miRNAs that regulate target gene
hsa-mir-142-3p
Nearest miRNA
hsa-mir-12123/Upstream/103198; hsa-mir-10400/Downstream/925901;
Nearest TSS
ENST00000518652/Upstream/9698; ENST00000520820/Downstream/10062;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/104166, chr8-CpG: 106/Downstream/9812
Upstream sequence
cgagaagttagaaatcaataacataaattcataaatttgtggaaattaaacaacacactcttaaatcaccaatgggtcaaagaagaaataacaagggaaa
Downstream sequence
acctgcatgctccctccctcaaggggctgagcgcaatgggttcaagtgagtggagtttgcccctgccagcgccaaagcagccagctagctccagcatgcg
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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