Basic Information
VIS ID
TVIS20002693
Fusion event
HPV-PRUNE2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr9
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
79516023/76901107 (Hg38)
End
79516023/76901107 (Hg38)
Location type
Intronic
Target gene
PRUNE2
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-196a-5p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-769-5p ; hsa-mir-382-3p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-4671-3p ; hsa-mir-593-5p ; hsa-mir-6124 ; hsa-mir-4733-3p ; hsa-mir-3148 ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-570-5p ; hsa-mir-548ba ; hsa-mir-548ai ; hsa-mir-548ag ; hsa-mir-4796-3p ; hsa-mir-548m ; hsa-mir-196b-5p ; hsa-mir-301a-3p ; hsa-mir-3666 ; hsa-mir-130a-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-4295 ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-101-2/Upstream/6091023; hsa-let-7a-1/Downstream/7068641;
Nearest TSS
ENST00000422679/Upstream/31925; ENST00000376708/Downstream/4934;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/441462, chr9-CpG: 75/Downstream/4780
Upstream sequence
aaaccctgtccctactaaaactacaaaattagctgggcgtggtggcacatgcctgtaattccagctactcggggggctgaggcaggagaatcgcttgaac
Downstream sequence
ctctctcacgctacgtgtccactgcacgtattaccgtatcagggactcaggctcatgggacatcggccatctttaacattgccagactctgtaccagagg
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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