Basic Information
VIS ID
TVIS20002716
Fusion event
HPV-CNTNAP2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;EU918767.1
Host Sequence
Chromosome
chr7
Cytoband
q35
Reference genome
GRCh37/hg19
Start
147612619/147915527 (Hg38)
End
147612619/147915527 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
CNTNAP2
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-99b-5p ; hsa-mir-4444 ; hsa-mir-6079 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-4428 ; hsa-mir-571 ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u
Nearest miRNA
hsa-mir-10399/Upstream/537406; hsa-mir-153-2/Downstream/3322894;
Nearest TSS
ENST00000635602/Upstream/18498; ENST00000631199/Downstream/129065;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1798535, chr7-CpG: 33/Downstream/423875
Nearest cancer related gene
CNTNAP2(TSG, No orient, 0)
Upstream sequence
GAATCACATGCCTCCGGTTCTAGTGATGCTCCTTTCCAATAAAACAAATACTCCCTAAGCAGATAAATAAATAATCAAACACAAATAAATGTCATACATG
Downstream sequence
AAATAAAtgtgtgtgcatgtgcttgtctgtgtgtgtgtgtatAAAATAAAATGTTAAAATGGACAGCTATCAATATATTTTCTTTCTAGATACATAAACG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate