VISDB - VIS Detail

Basic Information

VIS ID

TVIS20002731

Fusion event

HPV-VMP1 integration

Validated

Detection method

HIVID

Data source

Curated

Sample type

Tumor

Disease

Not given

Quality evaluation

Normal

Reported year

2015

PubMed ID

25581428

Virus Sequence

Virus name

HPV

Subtype

HPV16

Reference genome

NC_001526.2

Host Sequence

Chromosome

chr17

Cytoband

q23.1

Reference genome

GRCh37/hg19

Start

57917330/59839969 (Hg38)

End

57917330/59839969 (Hg38)

Location type

Intronic

Target gene

VMP1

miRNAs that regulate target gene

hsa-mir-210-3p ; hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-296-3p ; hsa-mir-25-3p ; hsa-mir-4776-3p ; hsa-mir-744-3p ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-7159-5p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-4694-5p ; hsa-mir-5186 ; hsa-mir-7978 ; hsa-mir-181a-3p ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-1324 ; hsa-mir-4709-5p ; hsa-mir-4272 ; hsa-mir-6856-3p ; hsa-mir-513b-3p ; hsa-mir-505-3p ; hsa-mir-421 ; hsa-mir-3161 ; hsa-mir-622 ; hsa-mir-4761-5p ; hsa-mir-624-3p ; hsa-mir-132-3p ; hsa-mir-212-3p ; hsa-mir-4482-3p ; hsa-mir-7159-3p ; hsa-mir-138-2-3p ; hsa-mir-4282 ; hsa-mir-4698 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-555 ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-5680 ; hsa-mir-4506 ; hsa-mir-150-3p

Nearest miRNA

hsa-mir-10226/Upstream/473815; hsa-mir-1250/Downstream/1297;

Nearest TSS

ENST00000595228/Upstream/2018; ENST00000477179/Downstream/38793;

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/132222, chr17-CpG: 73/Downstream/52712

Upstream sequence

ACACATCGAAAACATCTCTGCCCTGCTCCTTCACTAATCCCCAGGGCCCTCCAGGTATGTCAAGCTGTTCAATATACACGTTAAGCCTTTGGCATTAAGT

Downstream sequence

GGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATAC

Reference

Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.