Basic Information
VIS ID
TVIS20002732
Fusion event
HPV-RPS6KB1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr17
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
58001540/59924179 (Hg38)
End
58001540/59924179 (Hg38)
Location type
Intronic
Target gene
RPS6KB1
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-103a-3p ; hsa-mir-98-5p ; hsa-mir-16-5p ; hsa-mir-877-3p ; hsa-mir-877-5p ; hsa-mir-15a-5p ; hsa-mir-107 ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-548c-3p ; hsa-mir-4668-3p ; hsa-mir-5571-3p ; hsa-mir-6838-5p ; hsa-mir-1253 ; hsa-mir-3161 ; hsa-mir-145-5p ; hsa-mir-138-2-3p ; hsa-mir-451b ; hsa-mir-599 ; hsa-mir-580-3p ; hsa-mir-6770-5p ; hsa-mir-500b-5p ; hsa-mir-362-5p ; hsa-mir-500a-5p ; hsa-mir-455-5p ; hsa-mir-200c-3p ; hsa-mir-218-5p ; hsa-mir-1271-3p ; hsa-mir-4275 ; hsa-mir-550a-3-5p ; hsa-mir-550a-5p ; hsa-mir-550b-2-5p
Nearest miRNA
hsa-mir-10226/Upstream/82842; hsa-mir-1250/Downstream/118846;
Nearest TSS
ENST00000595228/Upstream/17191; ENST00000587622/Downstream/7141;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/30519, chr17-CpG: 23/Downstream/40306
Upstream sequence
aattgcttgaacctgggaggcagaggttgcggtgagtgagccaagatcgcaccactgcactctagcctgggcgacagagggagactccgtctcaaaaaaa
Downstream sequence
ttagccaggtgtggtggcaggtgcctgtagtcccagctacttgggaggctgaggcaggagaatcacttgaacctgggaggcggaggttgcagtgagctga
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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