Basic Information
VIS ID
TVIS20002755
Fusion event
HPV-chr1:p22.2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
90283641/89818082 (Hg38)
End
90283641/89818082 (Hg38)
Fragile sites / regions
FRA1D
Nearest miRNA
hsa-mir-101-1/Upstream/3460395; hsa-mir-11399/Downstream/4028750;
Nearest TSS
ENST00000473358/Upstream/54537; ENST00000525774/Downstream/2786;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/54468, chr1-CpG: 147/Downstream/2548
Nearby gene
LRRC8D(+2932) ;
Upstream sequence
TATCAAAAGCTTGGCTGCTTAAGACGTGCTTGCCTTAACTTGTTTGGTTACCCACTTGCTCTCTGTTGGTCTTTCTTTCTGCCTGTAGCTTTTTCTCTGT
Downstream sequence
CTTGTTTCAGAAGACTTAATAGGAAGGTTCACTGAGCCTTCTTATTACGAATGTTTCAGGTAACAGCTGGACCAAAACAAGAAGCTAAGCATTTAGGTAC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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