Basic Information
VIS ID
TVIS20002759
Fusion event
HPV-OBSCN integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
q42.13
Reference genome
GRCh37/hg19
Start
228389399/228201698 (Hg38)
End
228389399/228201698 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
OBSCN
miRNAs that regulate target gene
hsa-mir-155-5p
Nearest miRNA
hsa-mir-101-1/Upstream/104357; hsa-mir-1182/Downstream/195350;
Nearest TSS
ENST00000473358/Upstream/27148; ENST00000493977/Downstream/6432;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/26708, chr1-CpG: 251/Downstream/10072
Upstream sequence
caggagttcgagaccaacctggccaatggtgaaacctcgtctctactaaaaatacaaaaattagtcagatgggtggtgggcacctgtaaactcagctact
Downstream sequence
caggaggctgaggcaggagaatcacttgaacccaggaggcagaggttgcagtgagctatcgcaccactgcactccagcctgggcaacacagcaagactcc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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