Basic Information
VIS ID
TVIS20002761
Fusion event
HPV-PDSS1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr10
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
27029171/26740242 (Hg38)
End
27029171/26740242 (Hg38)
Location type
Intronic
Target gene
PDSS1
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-124-3p ; hsa-mir-98-5p ; hsa-mir-106b-5p ; hsa-mir-320a
Nearest miRNA
hsa-mir-1265/Upstream/2464461; hsa-mir-107/Downstream/1549016;
Nearest TSS
ENST00000439456/Upstream/5591; ENST00000477034/Downstream/83048;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/42083, chr10-CpG: 85/Downstream/119995
Upstream sequence
gaaaagaaaaTATGTGTCCTTATCAATTAGTTTTGTCATTTTTTCCTAAAAGCTATCTCCTATTGCAGAAACATTATGTTTTTAAAGAGGAATGAGTTGA
Downstream sequence
TCAACAGCCTTGATCATGGGATCTAAAGTCTTCAGCTGCAggctgggcacggcagctcatgcctgtaatcccagcactttgggaggccgaggtgggcgga
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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