Basic Information
VIS ID
TVIS20002762
Fusion event
HPV-chr10:q11.21 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
43053915/42558467 (Hg38)
End
43053915/42558467 (Hg38)
Fragile sites / regions
FRA10G
Nearest miRNA
hsa-mir-1265/Upstream/6917215; hsa-mir-107/Downstream/439096;
Nearest TSS
ENST00000439456/Upstream/82839; ENST00000439913/Downstream/36200;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/5443, chr10-CpG: 56/Downstream/79608
Nearby gene
FXYD6P1(-2740) ; EIF3LP2(+8209) ;
Upstream sequence
TGGGAATCCTGAATGTCACCCACTCAGCCTCTCCGTTTCCCAAAGCAGTTCTTAGTTTGAAAACCACCAGTTGTGATGAGTCCTTTCGGTTTCCCCACAA
Downstream sequence
GGAAAAAAAATTGATTAAACAAAAACACCTGACCTGAAGTTTTCCCTTCCTAAGAGAGGTGATAGTGGCCCATCAGTGCCCAGGGTGACAAGCCCAGTGC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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