Basic Information
VIS ID
TVIS20002763
Fusion event
HPV-chr10:q23.1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr10
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
82203380/80443624 (Hg38)
End
82203380/80443624 (Hg38)
Fragile sites / regions
FRA10D
Nearest miRNA
hsa-mir-1265/Upstream/4891071; hsa-mir-107/Downstream/5821070;
Nearest TSS
ENST00000439456/Upstream/23626; ENST00000469149/Downstream/10542;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/34463, chr10-CpG: 119/Downstream/10176
Nearby gene
PRXL2A(-6509) ;
Upstream sequence
aaaggagtctgaacgcattgttcagtatgccaattgcatttttcagctccaaaatttttgctagactcttttaattatatcaatctcttcgttaaatttt
Downstream sequence
cctgttagaattctgaatttcttctttgtgttttcttgaatgtctttgattttgctcaagaaaaaaaaacaaaacaacaacaacaacaaaaacaaaaaac
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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