Basic Information
VIS ID
TVIS20002767
Fusion event
HPV-LOC105376654 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
45522294/45500744 (Hg38)
End
45522294/45500744 (Hg38)
Location type
Intronic
Target gene
LOC105376654
Nearest miRNA
hsa-mir-129-2/Upstream/1919261; hsa-let-7a-2/Downstream/190960;
Nearest TSS
ENST00000527297/Upstream/101296; ENST00000525926/Downstream/13058;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/145052, chr11-CpG: 115/Downstream/148903
Upstream sequence
caatctcctaggactgttgtgaagattaaatcaaagcaatcatcaagtgaagatctcagcagtgtttgactcacagtaagtgctcattaaatatttagct
Downstream sequence
actattACTATGTTCAGCTGTTGATAGTTACCTTTGGCCTCAATTTCTGGTTCAATCTATTTCAGCCAGGTAATAGGGTCACATGACACAAATCCTAGTA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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