Basic Information
VIS ID
TVIS20002768
Fusion event
HPV-chr11:q14.1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
81409305/81698263 (Hg38)
End
81409305/81698263 (Hg38)
Nearest miRNA
hsa-mir-10392/Upstream/2276037; hsa-let-7a-2/Downstream/192478;
Nearest TSS
ENST00000527297/Upstream/935437; ENST00000526154/Downstream/272731;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/2257103, chr11-CpG: 25/Downstream/991280
Upstream sequence
GTCTTAAAAGGAAATAAAATAAAAACGTACTGATAAGCTGCTGAGTTAATTGCTGTGTTCAAATTATCCTATCTATTTTTACCTTTAAAAATGTATGCCC
Downstream sequence
TACTCTTTTATTACCATCTGCAGAGATGAAAAACTATAATTTTTGCACTTGAATTAAAGCCATGCTCACCTACTTTAAAAATAATAACTGATACTTCATG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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