Basic Information
VIS ID
TVIS20002770
Fusion event
HPV-chr11:q23.3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
117818766/117948051 (Hg38)
End
117818766/117948051 (Hg38)
Fragile sites / regions
FRA11B
Nearest miRNA
hsa-mir-10392/Upstream/4497963; hsa-let-7a-2/Downstream/695949;
Nearest TSS
ENST00000527297/Upstream/18592; ENST00000531365/Downstream/38297;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/71213, chr11-CpG: 62/Downstream/37872
Upstream sequence
ggcaataccactcaagacataggcatgggcaaagatttcatgacgaaaatgtcaaaagcaattgcaacaaaagcgaaaattgataagtggggtctaatta
Downstream sequence
aactaaagagcttctgcacagccaaagaaaccataatcagagtgaacagacaatctacagaacgggagaaaatttttgcaacctatccatctgacaaagg
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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