Basic Information
VIS ID
TVIS20002772
Fusion event
HPV-chr12:q15 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr12
Cytoband
q15
Reference genome
GRCh37/hg19
Start
70840718/70446938 (Hg38)
End
70840718/70446938 (Hg38)
Nearest miRNA
hsa-let-7i/Upstream/862115; hsa-mir-1178/Downstream/8972319;
Nearest TSS
ENST00000382841/Upstream/46728; ENST00000548924/Downstream/21142;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/79666, chr12-CpG: 52/Downstream/162906
Nearby gene
RNU4-65P(-3015) ;
Upstream sequence
aaacaaacaaacaaacatgaaaaggcaaacaaacaTGAAAAGGCAAATGATAGAACTGGCCAGTTCCATTTCTAATGGCCTGAGTGGACTCATTCTAGAA
Downstream sequence
ttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttgagacggagt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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