Basic Information
VIS ID
TVIS20002773
Fusion event
HPV-NAV3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr12
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
78563031/78169251 (Hg38)
End
78563031/78169251 (Hg38)
Location type
Intronic
Target gene
NAV3
miRNAs that regulate target gene
hsa-mir-29a-3p ; hsa-mir-21-5p
Nearest miRNA
hsa-let-7i/Upstream/8584428; hsa-mir-1178/Downstream/1250006;
Nearest TSS
ENST00000382841/Upstream/46989; ENST00000548948/Downstream/10169;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1103089, chr12-CpG: 38/Downstream/635033
Upstream sequence
CCATTTCTAATGGCCTGAGTGGACTCATTCTAGAAttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttt
Downstream sequence
tttttttttttttttttttttttttgagacggagtctcactctgttgcccagactggagtacaatgctacaatcttggctcactgcaacctctgcctccc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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