Basic Information
VIS ID
TVIS20002774
Fusion event
HPV-LRRIQ1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
85469287/85075509 (Hg38)
End
85469287/85075509 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
LRRIQ1
Nearest miRNA
hsa-let-7i/Upstream/3917048; hsa-mir-1178/Downstream/1669559;
Nearest TSS
ENST00000382841/Upstream/30728; ENST00000526363/Downstream/84006;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/162459, chr12-CpG: 56/Downstream/204591
Upstream sequence
aaaaaagttcagccctcatgatgcttagaaattattgtatcataaaagaagaaaaaaatcctgtgaataaagagatatttggaaagcaaaaaggagctca
Downstream sequence
tggaaattaaaaatatgataacaatgaaataatcaaaagaaggatagaacaataaagtttaaagaaaatagaagagagaaaatagcagagaaaagatcag
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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