Basic Information
VIS ID
TVIS20002780
Fusion event
HPV-RSPRY1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr16
Cytoband
q13
Reference genome
GRCh37/hg19
Start
57226432/57192520 (Hg38)
End
57226432/57192520 (Hg38)
Location type
Intronic
Target gene
RSPRY1
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-21-5p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1225/Upstream/288167; hsa-mir-11401/Downstream/579769;
Nearest TSS
ENST00000527434/Upstream/6187; ENST00000561641/Downstream/12077;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/5849, chr16-CpG: 70/Downstream/52374
Upstream sequence
atagctgtgtctaagaagctgtaccaacttgtactgtgagcttcttgagggcaggtaccccatgttttcctctttgtattctcaccttctagcccatgcc
Downstream sequence
TCCTTACTCTATCCTAGGCCTAAATTTTATTTTTTAGTAAATTATTTGAATGCTGAAAGGATTTGTCTTTTCTCCTTTGTACCATTTTAGGTCAGGACTA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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