Basic Information
VIS ID
TVIS20002781
Fusion event
HPV-TEX2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr17
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
62240400/64163040 (Hg38)
End
62240400/64163040 (Hg38)
Location type
Intronic
Target gene
TEX2
miRNAs that regulate target gene
hsa-mir-32-5p ; hsa-mir-26b-5p ; hsa-mir-423-5p
Nearest miRNA
hsa-mir-10226/Upstream/1218728; hsa-mir-1250/Downstream/337734;
Nearest TSS
ENST00000595228/Upstream/6806; ENST00000617071/Downstream/25414;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/16276, chr17-CpG: 92/Downstream/99403
Upstream sequence
TTCAGAGTAGTTGGGGTTGCTTACTTTTCATTTTTAATTCTTTAGGTTTTGTAAGTTACACACTTCAAGCATTATAGATGATCCTCTTTTTACTACTGAA
Downstream sequence
CTGAATATACCTCATGAGACCCACTCACAGGGCCCTGCTCAGCCCTGGCACTCATAAAAATATGAAAGAGTCAAGAATGCTTTAAGAACttttttcttcc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate