Basic Information
VIS ID
TVIS20002782
Fusion event
HPV-L3MBTL4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr18
Cytoband
p11.31
Reference genome
GRCh37/hg19
Start
6139824/6139825 (Hg38)
End
6139824/6139825 (Hg38)
Location type
Intronic
Target gene
L3MBTL4
miRNAs that regulate target gene
hsa-let-7b-5p
Nearest miRNA
hsa-mir-3976/Upstream/298992; hsa-mir-1-2/Downstream/234536;
Nearest TSS
ENST00000575820/Upstream/114734; ENST00000578427/Downstream/116922;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/243575, chr18-CpG: 22/Downstream/144550
Nearest cancer related gene
L3MBTL4(TSG, No orient, 0)
Upstream sequence
agattatgcgtgggctcagcaacatggacttccactcaccaaagctgacctggctatggccacttctgagtgcctaatctcccagcagtagagaccaaca
Downstream sequence
CACACCTCTGAGGCTCCTCTTCTGAGTCTGATGCCTTGGGCTTCCACTATCTGCCCACTGTTTCCACATCACTCAGGGAAGACTTTGGCACTGGCTCTCC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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