Basic Information
VIS ID
TVIS20002784
Fusion event
HPV-ZNF823 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
11833468/11722653 (Hg38)
End
11833468/11722653 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ZNF823
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-1181/Upstream/227031; hsa-let-7e/Downstream/980948;
Nearest TSS
ENST00000633603/Upstream/82877; ENST00000462251/Downstream/16229;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/27568, chr19-CpG: 42/Downstream/15891
Upstream sequence
TTTAATCtttaatttttgtggttacatagtaggtgtatatatatatatatgaggtacatgagacattttagtacaggcatgcactgtataataataatat
Downstream sequence
GTAGTCGAGTGTAATAGTAACAGCTGAAGGCTTTCCCACATTGTGTACATTTATAGGGTTTCTCTCCGGTGTGAGTTCTCTCATGTCTTAGATAGGTACT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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