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Viral Integration Site DataBase
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TVIS20002788
Basic Information
VIS ID
TVIS20002788
Fusion event
HPV-WDR92 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr2
Cytoband
p14
Reference genome
GRCh37/hg19
Start
68363654/68136522 (Hg38)
End
68363654/68136522 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
WDR92
miRNAs that regulate target gene
hsa-mir-1277-5p
;
hsa-mir-190a-3p
;
hsa-mir-5011-5p
;
hsa-mir-7151-3p
;
hsa-mir-6807-5p
;
hsa-mir-5095
;
hsa-mir-6849-3p
;
hsa-mir-4433a-3p
;
hsa-mir-6504-3p
;
hsa-mir-4433b-3p
;
hsa-mir-4700-3p
;
hsa-mir-129-5p
;
hsa-mir-8055
;
hsa-mir-498
;
hsa-mir-4465
;
hsa-mir-26b-5p
;
hsa-mir-26a-5p
;
hsa-mir-1297
;
hsa-mir-1264
;
hsa-mir-8070
;
hsa-mir-6778-3p
;
hsa-mir-4679
;
hsa-mir-1976
;
hsa-mir-3653-5p
;
hsa-mir-150-5p
;
hsa-mir-6747-3p
;
hsa-mir-6727-3p
;
hsa-mir-4722-3p
;
hsa-mir-6814-5p
;
hsa-mir-5697
;
hsa-mir-562
;
hsa-mir-4762-3p
;
hsa-mir-6843-3p
;
hsa-mir-6848-3p
;
hsa-mir-640
;
hsa-mir-3192-3p
;
hsa-mir-378a-5p
;
hsa-mir-1193
;
hsa-mir-6759-3p
;
hsa-mir-3151-3p
;
hsa-mir-1237-3p
;
hsa-mir-2392
;
hsa-mir-4662a-5p
;
hsa-mir-575
;
hsa-mir-4676-5p
;
hsa-mir-6858-3p
;
hsa-mir-4284
;
hsa-mir-4772-3p
;
hsa-mir-4638-5p
;
hsa-mir-1307-3p
;
hsa-mir-1304-3p
;
hsa-mir-6741-3p
;
hsa-mir-1281
;
hsa-mir-4485-5p
;
hsa-mir-4532
;
hsa-mir-1247-3p
;
hsa-mir-6890-3p
;
hsa-mir-122-3p
;
hsa-mir-106a-5p
;
hsa-mir-106b-5p
;
hsa-mir-17-5p
;
hsa-mir-186-3p
;
hsa-mir-20a-5p
;
hsa-mir-20b-5p
;
hsa-mir-302a-3p
;
hsa-mir-302b-3p
;
hsa-mir-302c-3p
;
hsa-mir-302d-3p
;
hsa-mir-302e
;
hsa-mir-372-3p
;
hsa-mir-373-3p
;
hsa-mir-4731-5p
;
hsa-mir-5089-5p
;
hsa-mir-512-3p
;
hsa-mir-519d-3p
;
hsa-mir-520a-3p
;
hsa-mir-520b
;
hsa-mir-520c-3p
;
hsa-mir-520d-3p
;
hsa-mir-520e
;
hsa-mir-520g-3p
;
hsa-mir-520h
;
hsa-mir-526b-3p
;
hsa-mir-5589-5p
;
hsa-mir-619-5p
;
hsa-mir-6506-5p
;
hsa-mir-93-5p
Nearest miRNA
hsa-mir-1301/Upstream/1778194; hsa-mir-10b/Downstream/967160;
Nearest TSS
ENST00000437798/Upstream/25574;
ENST00000430742/Downstream/2263;
Nearest CpG islands
None/Target,
chr2-CpG: 135/Upstream/738810
,
chr2-CpG: 70/Downstream/20530
Upstream sequence
ATTTTATTTCCATTCTTTTATTTAAATTATTTAGTGGGTGTTCAATAATTCTGGCTAGAAAGACAAAATATGTTCTTGCTTTATGACACAAGTGTTAGCA
Downstream sequence
GCAACGGAGTAAGTTCTCACTtcctgagcaacttgtatattttaatcttatggaaacaaggaatctgtaactgatctttctttctttttatacttgagga
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Sample Information
×
Sample name
T6552
Sample type
Tumor
Gender
Female
CpG Island Information
×
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