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Viral Integration Site DataBase
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TVIS20002789
Basic Information
VIS ID
TVIS20002789
Fusion event
HPV-CNNM4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
97437495/96771758 (Hg38)
End
97437495/96771758 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
CNNM4
miRNAs that regulate target gene
hsa-mir-98-5p
;
hsa-mir-377-5p
;
hsa-mir-3148
;
hsa-mir-3202
;
hsa-mir-4257
;
hsa-mir-4476
;
hsa-mir-4668-5p
;
hsa-mir-5584-5p
;
hsa-mir-6086
;
hsa-mir-6876-5p
;
hsa-mir-7515
;
hsa-mir-876-3p
;
hsa-mir-6508-3p
;
hsa-mir-323a-5p
;
hsa-mir-4726-5p
;
hsa-mir-4640-5p
;
hsa-mir-765
;
hsa-mir-6077
;
hsa-mir-4646-5p
;
hsa-mir-7113-5p
;
hsa-mir-6895-5p
;
hsa-mir-9500
;
hsa-mir-4779
;
hsa-mir-575
;
hsa-mir-4676-5p
;
hsa-mir-769-3p
;
hsa-mir-450b-3p
;
hsa-mir-4314
;
hsa-mir-1260b
;
hsa-mir-1260a
;
hsa-mir-638
;
hsa-mir-8085
;
hsa-mir-4713-3p
;
hsa-mir-6731-5p
;
hsa-mir-760
;
hsa-mir-766-5p
;
hsa-mir-6506-5p
;
hsa-mir-619-5p
;
hsa-mir-3192-5p
;
hsa-mir-204-3p
;
hsa-mir-330-5p
;
hsa-mir-326
;
hsa-mir-1203
;
hsa-mir-1224-3p
;
hsa-mir-1306-5p
;
hsa-mir-6760-5p
;
hsa-mir-4325
;
hsa-mir-7703
;
hsa-mir-203a-3p
;
hsa-mir-3914
;
hsa-mir-32-5p
;
hsa-mir-92b-3p
;
hsa-mir-25-3p
;
hsa-mir-367-3p
;
hsa-mir-92a-3p
;
hsa-mir-363-3p
;
hsa-mir-6748-5p
;
hsa-mir-3190-3p
;
hsa-mir-654-5p
;
hsa-mir-541-3p
;
hsa-mir-4483
;
hsa-mir-1293
;
hsa-mir-6756-5p
;
hsa-mir-6766-5p
;
hsa-mir-6745
;
hsa-mir-363-5p
;
hsa-mir-7-5p
;
hsa-mir-194-3p
;
hsa-mir-3681-3p
;
hsa-mir-216a-3p
;
hsa-mir-128-3p
;
hsa-mir-6881-3p
;
hsa-mir-6780a-3p
;
hsa-mir-7111-3p
;
hsa-mir-3667-3p
;
hsa-mir-877-3p
;
hsa-mir-1247-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/7959304; hsa-mir-10b/Downstream/26520;
Nearest TSS
ENST00000437798/Upstream/10856;
ENST00000482716/Downstream/16832;
Nearest CpG islands
None/Target,
chr2-CpG: 135/Upstream/10287
,
chr2-CpG: 230/Downstream/43861
Upstream sequence
ctagttaacgtatgcattaaacctgaaatttatctgtagagacaatgcaatttcaactgaaattctagctgaattttttttggtagaaattgacaaaccg
Downstream sequence
GGAACACAGTTTAGATGGGTTCTTCAGATTCCCTGCTGATAAGAAATTAAATCCTTATCCCCATCATCCTTTCGGAGTCTCTCAGAGAATCTGCACCAGG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Sample Information
×
Sample name
T6552
Sample type
Tumor
Gender
Female
CpG Island Information
×
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