Basic Information
VIS ID
TVIS20002790
Fusion event
HPV-chr2:q21.2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr2
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
133052987/132295414 (Hg38)
End
133052987/132295414 (Hg38)
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/38334; hsa-mir-10b/Downstream/138297;
Nearest TSS
ENST00000437798/Upstream/1037; ENST00000622084/Downstream/51883;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/37247, chr2-CpG: 79/Downstream/57329
Nearby gene
ZNF806(+9378) ;
Upstream sequence
CATTTGTGACTTCAAGAAATAGGAAGGAAAATGGAATAAAGAATGACTTGAAAGCCACTGAGCCTTGAAGACTTGTTTCCCTTATTAGTTTCCCTTATTA
Downstream sequence
gtatcccaactccagcaataccttgtcctgagggaaacttcaattcataaacccatgaatttctatgactttatcacacatctcatgttcccattttttt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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