Basic Information
VIS ID
TVIS20002796
Fusion event
HPV-MICAL3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
18393766/17911000 (Hg38)
End
18393766/17911000 (Hg38)
Location type
Intronic
Target gene
MICAL3
Nearest miRNA
hsa-mir-3198-1/Upstream/146741; hsa-let-7a-3/Downstream/69868;
Nearest TSS
ENST00000624155/Upstream/4126; ENST00000443243/Downstream/90180;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/68978, chr22-CpG: 145/Downstream/89425
Upstream sequence
TCATAATCACAGGAACCTGGAGACCAGGAAACCTGGCAGGAAGGTGCCAGAAATCCCAGAAACTGAAAAGCCAAGGTGTGCAAGGAAGGGGTAGAGGAAG
Downstream sequence
TGAGGAGCCGGGTTGGGGGCTGGGGGAGGAAGAGGAGGTGATGCCAGGTTTCCAGGCATCTGTGAGTCTCTGCCAGCTGACTCCAGCCTGCATGTTTTGT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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